Clinical utility of circulating calprotectin to assist prediction and monitoring of COVID-19 severity: An Italian studyArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] 바이오마커, [키워드] Administered Admission assist Biomarker calprotectin Care chemiluminescent immunoassay circulating Circulating calprotectin clinical Cohort collected Concentration controls correlation COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients disease severity evaluate healthy individual ICU intubation Italian study median Patient positive airway pressure Respiratory Support risk risk assessment. Sample serological serum severity of COVID-19 Severity of disease significantly higher tested utility were used [DOI] 10.1002/jmv.28056 PMC 바로가기
Maternal SARS-CoV-2 sero-surveillance using newborn dried blood spot (DBS) screening specimens highlights extent of low vaccine uptake in pregnant womenArticle Published on 2022-11-302022-11-15 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Adults analyzed Antibody concentrations Antibody neutralization Blood complications contributing to COVID COVID-19 delta variant dose Dried blood spots fetal General population help highlight Hospital admissions Immunity IMPROVE information Intervention Maternal MONITOR natural infection Newborn newborn screening omicron outcomes pregnant women proportion reduction in representing Result SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 IgG antibodies serostatus specimen the SARS-CoV-2 the vaccine utility vaccination vaccination. Vaccine women [DOI] 10.1080/21645515.2022.2089498 PMC 바로가기
Evaluation of Procalcitonin’s Utility to Predict Concomitant Bacterial Pneumonia in Critically Ill COVID-19 PatientsArticle Published on 2022-11-012022-11-15 Journal: Journal of Intensive Care Medicine [Category] 바이오마커, [키워드] Antibiotic therapy AUC Bacteremia Bacterial Bacterial infection bacterial pneumonia baseline characteristics Concomitant conducted COVID-19 creatinine Critical Critical illness Critically ill patient Culture defined determine diagnosing diagnostic ENhance evaluate group hospitalized patients ICU ICU patient identify Ill in-hospital mortality intensive care intensive care unit Mortality multivariable multivariable model no difference no significant difference offer outcome Patient PCT Pneumonia positive predict Predictive procalcitonin procalcitonin. receiver operating characteristics Regression model retrospective cohort study ROC SARS-CoV-2 secondary bacterial pneumonia serum creatinine Severe COVID-19 pneumonia Severity of disease specificity threshold utility variable vital signs was used while with COVID-19 [DOI] 10.1177/08850666221108636 PMC 바로가기
Diagnostic accuracy of a novel SARS CoV-2 rapid antigen test and usefulness of specimens collected from the anterior nasal cavityArticle Published on 2022-11-012022-11-15 Journal: International Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] Accuracy Ag-RDT age Antigen collected criteria cycle threshold Cycle threshold value diagnostic Diagnostic accuracy enrolled Hospitalization meet moderate nasal nasal mucosa nasopharyngeal Patient polymerase chain primary end point provide Rapid diagnostic test real-time polymerase chain reaction remained SARS CoV-2 SARS-CoV-2 sensitivity Sensitivity and specificity specificity specimen specimens utility Viral load Viral load. World Health Organization [DOI] 10.1016/j.ijid.2022.09.018 PMC 바로가기
Comparative study of the usefulness of risk score assessment in the early stages of COVID-19 affected pregnancies: Omicron variant versus previous variantsArticle Published on 2022-11-012022-11-16 Journal: The journal of obstetrics and gynaecology research [Category] SARS, 변종, 치료기술, [키워드] affected age Blood C-reactive protein Comparative Course COVID-19 D-dimer level Delta Deterioration disease disease onset early stage Epidemic evaluate examination findings Frequency group groups less no significant difference not significantly different omicron Omicron variant parameter Patient Platelet Pneumonia Pregnancy pregnant Prognosis risk risk scoring significantly lower two group utility variant Variant of concern. variants was increased worsening [DOI] 10.1111/jog.15387 PMC 바로가기
Clinical decision analysis of elective delivery vs expectant management for pregnant individuals with COVID-19–related acute respiratory distress syndromeResearch article Published on 2022-11-012022-10-05 Journal: American journal of obstetrics & gynecology MFM [Category] 임상, [키워드] acute respiratory distress acute respiratory distress syndrome age Analysis cesarean delivery children clinical decision Clinical decision analysis comparable Complication Computer simulation COVID-19 Critical illness death Decision analysis determine Elective Evidence gestation hospital individual individuals iteration lack likelihood management Maternal Model Mortality mortality risk Neonatal Neonates neonatology obstetrics outcome outcomes parameter performed Pregnancy pregnant premature birth quantification risk sensitivity analysis severity spontaneous labor survival syndrome the mean utility Ventilated [DOI] 10.1016/j.ajogmf.2022.100697 [Article Type] Research article
Genome-wide detection of human variants that disrupt intronic branchpointsArticle Published on 2022-11-012022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] 변종, [키워드] Alter approach branchpoint Candidates characterized comparable COVID-19 Critical database demonstrated detect disease Disease genetics disrupt disrupting eight elements enzyme exonic feature heterozygous human gene human population identify initiated intron Intronic intronic variant ITPKB lymphoma machine-learning motif nucleotides upstream pathogenic Patient Pneumonia rare variant reported RNA sequencing RNA splicing sequencing data single-nucleotide Software splicing. STAT2 utility variant variants Variation [DOI] 10.1073/pnas.2211194119 PMC 바로가기
Neutralizing SARS-CoV-2 Spike Antibodies against Omicron in Paired Samples after Two or Three Doses of mRNA VaccineArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] addition antibodies antibody Beta booster dose confounder COVID-19 death Delta demonstrated detect eliminated Hospitalization Immune escape mRNA mRNA vaccination mRNA vaccine neutralization neutralization activity Neutralizing neutralizing capacity Neutralizing titer omicron Omicron variant other variant protection provide reactive Sample SARS-CoV-2 SARS-CoV-2 antibody testing seroprevalence. Serum Neutralization significant increase significantly higher spike spike IgG tested the spike protein the vaccine unique utility Vaccine vaccine response variant variants of concern [DOI] 10.1128/spectrum.02046-22 PMC 바로가기
Multiplex PCR Detection of Respiratory Tract Infections in SARS-CoV-2-Negative Patients Admitted to the Emergency Department: an International Multicenter Study during the COVID-19 PandemicArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome Adults age age and sex association Bacterial caused Characteristics children circulating coronavirus coronavirus disease country COVID-19 COVID-19 pandemic detect detection determine diagnostic Emergency emergency department etiological agent Europe Evidence hospital human coronavirus Human rhinovirus Infection Intervention logistic regression model métapneumovirus Middle East multicenter study Multiplex PCR multiplex PCR assay Nasopharyngeal swab pandemic Panel pathogen Patient PCR prevalent respiratory respiratory pathogen respiratory syncytial virus respiratory tract respiratory tract infection respiratory viruses SARS-CoV-2 significantly higher Stratification Symptom symptomatic Symptoms target targets tested tract utility variety viral infection Viral infection. viruses [DOI] 10.1128/spectrum.02368-22 PMC 바로가기
A Robust, Highly Multiplexed Mass Spectrometry Assay to Identify SARS-CoV-2 VariantsArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome Care characterized circulation Clinical studies collected coronavirus defined Delta demonstrated diagnostic diagnostic capability effort functional health system health systems identify increasingly Infection prevention Iota Laboratory MALDI-TOF mass molecular MOST multiplex New York City omicron Panel Patient Patient care polymorphism Population public health measures public health systems RNA robust RT-PCR SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant seeking sensitivity specificity specimen Spectrometry Surveillance target tested Transmissibility USA utility vaccination variant variant call variant panel. virus WGS while whole-genome sequencing [DOI] 10.1128/spectrum.01736-22 PMC 바로가기